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2 edition of Syntheses and reactions of trichloromethyl azines and diazines. found in the catalog.

Syntheses and reactions of trichloromethyl azines and diazines.

John Roger Ferguson

Syntheses and reactions of trichloromethyl azines and diazines.

by John Roger Ferguson

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Published by University of Salford in Salford .
Written in English


Edition Notes

PhD thesis, Chemistry.

SeriesDX187171
ID Numbers
Open LibraryOL18952453M

Sweta D. Desai et al.: Synthesis of a Novel Class of Some 1,3,5-triazine Derivatives and their Anti-HIV Activity Synthesis of a Novel Class of Some 1,3,5-Triazine Derivatives and their Anti-HIV Activity Sweta D. Desai1 Kishor R. Desai1 Kishor H. Chikhalia2* Christophe Pannecouque3 and Erik De Clercq3 1Department of Chemistry, Veer Narmad South Gujarat University, Surat , Gujarat, India. Knorr pyrazole synthesis The Knorr pyrazole synthesis is an organic reaction used to convert a hydrazine or its derivatives and a 1,3-dicarbonyl compound to a pyrazole using an acid catalyst. The mechanism begins with an acid catalyzed imine formation, where in the case of hydrazine derivatives the attack can happen on either carbonyl carbon.

coupling reactions of aldehydes, amines and trimethylsilyl cyanide (TMSCN) to prepare α-amino nitriles using p-toluenesulfonic acid (p-TsOH) catalyst in ethanol under mild reaction conditions (Scheme Ι). Excellent yields of α-amino nitriles were obtained by carrying out the reactions in ethanol as solvent at RT in by: 4. The molecules 8(a–f) showed the absence of –NH peak in their IR, and the disappearance of –NH in 1 H NMR spectrum evidenced the cyclization of the product. In the IR spectrum, the stretching frequency at cm −1 disappeared, and also there is no stretching frequency for 2-chloroformyl quinoline at cm −1.A peak at δ for a proton of –NH disappeared, and new peaks were Cited by: 2.

The products and mechanism of hydrolytic decomposition of a series of 1,3-dialkylacyltriazenes were studied in alkaline buffers. In general the mechanism of decomposition involves deacylation leading to the formation of the parent 1, by: Scheme I-Syntheses of 3-aryl(2-quinolyl)rhodanines, 2-arylimino(m-methoxyphenyl)(2-quinolyl)rhodanines and l-arylmethyl(2-quinolylidene)imidazolones 3 Results and Discussion The compounds IIla-jgave the elemental analysis results in full agreement with the proposed structures (Table I). Their infrared spectra did not show anyCited by: 2.


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Syntheses and reactions of trichloromethyl azines and diazines by John Roger Ferguson Download PDF EPUB FB2

The reactions of 2- and 3-dichloromethylpyridines and dichloromethylpyrazine with carbon tetrachloride in the presence of aqueous or solid alkali and an interphase catalyst lead to the corresponding trichloromethyl-substituted azines.

The CCl4-solid KOHcrown-6 system, in the use of which trichloromethyl-substituted heterocycles were obtained in preparative yields, was the most Cited by: 1. Cyclohexanespiro-3'-oxaziridine transfers its NH group to N- O- S- and C-nucleophiles, thus making possible the syntheses of azines, hydrazines, diaziridines, hydrazino acids.

Title: “Tele Nucleophilic Substitutions of Hydrogen in m-(Trichloromethyl)-nitro-benzenes and 3-(Trichloromethyl)pyridines”, Varvounis, G. Invited lecture, Abstracts Book (), pp 11 th Eurasia Conference on Chemical Sciences, Syntheses and reactions of trichloromethyl azines and diazines.

book Dead Sea, Jordan, October Abstract. In order to produce a new lead for anti-tubercular drug a series of novel 2-trichloromethyl quinazoline derivatives bearing substituted secondary amine group at the 4 th position were designed, synthesized and evaluated for their in vitro anti-tubercular activity against bacterial strain of M.

tuberculosis H37Rv ATCC (American Type Culture Collection) by Alamar Blue assay method (MABA). Reactions of 2-arylchloro-6H-1,3-thiazinones with sodium sulfide in aqueous alcohol at 18–20°C led to the formation of a readily separable mixture of 2-arylsulfanyl-6H-1,3-thiazinone sodium salts (yield >70%) and bis(2-aryloxo-6H-1,3-thiazinyl) sulfides (<10%).

The latter can also be obtained in more than 50% yield by treatment of 2-arylsulfanyl-6H-1,3-thiazin-6 Author: V.

Kuklin, L. Mikhailov, G. Mironova, B. Ivin. The reactions of 3-nitrorifluoromethyl- and 3-nitrotrichloromethyl-2H-chromenes with thiols and aromatic amines proceed via the nucleophilic addition type to the activated double bond to.

One-pot sequential reactions of aryldiazonium salts with amidines followed by the treatment of I2/KI under basic conditions provide 2,5-disubstituted tetrazoles in moderate to excellent yields. This one-pot synthesis has several advantages such as mild reaction conditions, short reaction time, convenient workup, and high yields, making this methodology by: Metalation Reactions of Pyridines, Quinolines, and Isoquinolines with Ate Bases and Their Alkali Metal Salt-Modified Congeners, by Costa Metallinos, Kathryn Stromski.

Lithiations and Grignard Reactions on Pyrimidine and Quinazoline, by Andrej Kolarovic. Other Stoichiometric Metalation Reactions on Pyrimidine and Quinazoline, by Philippe C.

Gros. The one-pot synthesis of ten 5-carboxyisoxazoles from the cyclocondensation of β-alkoxyvinyl trichloromethyl ketones [CCl 3 C(O)C(R 2) C(R 1)OR, where R 1, R 2 =H, Me and R=Me, Et] and 2-trichloroacetyl cyclohexanone with hydroxylamine is reported.

This work shows that the trichloromethyl group attached to β-alkoxyvinyl trichloromethyl ketones (a heterocyclic CCC building block) is an Cited by: The synthetic procedures for the intermediates are shown in Scheme 1, Scheme 2, Scheme 3, Scheme 4 and Scheme 5 and for the title compounds – in Scheme 6, Scheme 7 and Scheme the synthesis of the title compounds 19 initially the intermediates arylsulfonylcarbamates and 4-substitutedpiperazine were refluxed in toluene for several hours, however, only a little of desired Cited by: Alkyne Metathesis in Synthesis: Syntheses of (+)-Ferrugine and Anatoxin-α.

Although much emphasis has been placed on the importance of alkene metathesis in organic synthesis, alkyne metathesis is also significant.

Metathesis reactions of alkynes with alkenes and metathesis reactions of alkynes with alkynes have both been carried out efficiently.

Result and Discussion Chemistry. The syntheses of 1-phenyl(4-(2-ethanoloxy) phenyl)aryl-1H-pyrazoles were achieved following the steps outlined in Scheme nes, that is, 3-aryl(4-hydroxyphenyl) propenones, 1 were prepared by the reaction of p-hydroxy acetophenone with substituted benzaldehydes following the Claisen-Schmidt : Anju Goyal, Sandeep Jain.

Reactions of heterocycles Five‐membered heterocycles are good nucleophiles •Reaction with bromine requires no Lewis acid and leads to substitution at all four free positions.

In Friedel–Crafts reactions the 2‐position is more reactive than the 3‐position Reactions of heterocycles. Succinate dehydrogenase inhibitors (SDHIs) are fungicides with an amide bond widely used to control plant diseases caused by phytopathogenic fungi.

Because. see article for more reactions. Abstract. The reaction of aryldiazonium salts with amidines followed by oxidative ring closure with I 2 /KI under basic conditions provides 2,5-disubstituted tetrazoles in good yields.

This one-pot synthesis offers mild reaction conditions, short reaction time and a. Treatment of 2-[bis(methylthio)methylene]malononitrile 1 with p -Chloroaniline afforded 2-[(4-chlorophenylamino) (methylthio) methylene] malononitrile 2a, of which upon reaction with hydrazine hydrate yielded 5-amino(4-chlorophenylamino)-1 H -pyrazolecarbonitrile 3.

This compound was utilized as a key intermediate for the synthesis of pyrazolo [5, 1-c] [1, 2, 4] triazines by Author: Wedad M.

Al-Adiwish, Maryam A. Abubakr, Naowara M. Alarafi. A series of novel 2-arylamino(arylsulfonyl)quinoxalines was synthesized through a newly developed approach.

All synthesized target compounds were screened for their cytotoxicities against cancer cell lines including PC3, A, HCT, HL60 and by: Synthesis of SF 5-containing benzisoxazoles, quinolines, and quinazolines by the Davis reaction of nitro-(pentafluorosulfanyl)benzenes Petr Beier and Tereza Pastýříková Beilstein J.

Org. Chem.9, – doi/bjoc Reactions in aqueous media are environmentally safe, devoid of any malign carcinogenic effects, have a simple work up procedure and especially important in industries. Thus, there is a need for developing multicomponent reactions (MCRs) in water and without the use of any harmful organic solvents.

Pyrano [2, 3-d] pyrimidine derivatives are. Synthesis of Novel 1,3,4, Oxadiazole from Chloro (amino pyrazoly) ketone carbohydrazide, their Fluorescence properties and Xanthine oxidase inhibitoryAuthor: Shailesh Prabhakar Ghag, Chitra Rajesh Kamath.

Beilstein J. Org. Chem.9, – Table 2: Synthesis of ortho-aminobenzophenones 10 and Entry 7 or 8 X Y Ar 10 or 11, Yield (%) 1 7a SF5 H Ph 10a, 98 2 7f SF5 H 4-PhC6H4 10f, 98 3 8a H SF5 Ph 11a, 93 4 8d H SF5 3,4-(MeO)2C6H3 11d, 98 5 8e H SF5 3,4,5-(MeO)3C6H2 11e, 98 Scheme 3: Synthesis of quinoline Scheme 4: Synthesis of quinoline Scheme 5: Synthesis of quinazoline Cited by: ring-opening reactions This classification is intimately related to the nature of the N-substituent, i.e., its electron-withdrawing or electron-donating properties.

From experimental data, it is clear that the nature of the N-substituent has a profound influence on the reactivity of 2-(bromomethyl)aziridines upon treatment with different.literature and reactions of β-azolyl enamines with diazo compounds and diazonium salts are not studied so far.

At the same time both pyrazolotriazines and azoles, such as 1,2,3-thiadiazoles and isoxazoles, exhibit interesting biological and chemical properties Therefore, it is a.